
Is Hormone Replacement Therapy Safe? What the Latest Research Says

Hormone replacement therapy (HRT) has been a game-changer for people dealing with the effects of hormone imbalance, whether due to menopause, andropause, thyroid issues, or other conditions. But is it actually safe?
At VNC Real Health PLLC, Valentine Ugwu, MD, FACOG, MBA, offers HRT tailored to your needs in Pearsall, TX. Here’s what the latest research reveals about this therapy and what you should consider before starting.
What is hormone replacement therapy?
HRT involves supplementing your body with hormones it’s no longer producing in adequate amounts (usually estrogen, progesterone, or testosterone). It can come in many forms, including:
- Pills or tablets
- Skin patches
- Creams or gels
- Implanted pellets
- Injections
HRT is often used to treat symptoms like hot flashes, mood swings, weight gain, low libido, fatigue, and brain fog. For men and women alike, restoring hormonal balance can significantly improve quality of life.
What the latest research says about HRT safety
Early studies raised concerns about HRT increasing the risk of breast cancer, heart disease, and blood clots. But newer, more nuanced research has painted a fuller picture, one that supports HRT as safe and beneficial when used appropriately.
Timing matters
Starting HRT before age 60 or within 10 years of menopause may carry fewer risks and more benefits.
Personalization is key
The type of hormone, dose, and delivery method all play a role in determining how well HRT works and its safety.
Testosterone therapy in men
This has not been shown to increase the risk of heart attacks in healthy individuals and may improve mood, energy, and sexual function.
Bioidentical hormones
By closely mimicking your body’s natural hormones, this method may be better tolerated than synthetic ones. Results can vary person to person.
Who should (and shouldn’t) consider HRT?
Like any medical treatment, HRT isn’t right for everyone. Here’s a quick breakdown:
You may benefit from HRT if you:
HRT might be right for you if you’re in your 40s-60s and experiencing perimenopause or menopause, have low testosterone with symptoms like fatigue or low libido, are dealing with mood, sleep, or metabolic challenges related to hormone imbalance, or want to strengthen your bones to prevent osteoporosis.
You may want to avoid HRT if you:
HRT may not be right for you if you have a history of hormone-sensitive cancers, past blood clots or stroke, untreated liver disease, or other health risks based on your personal or family medical history.
How to use HRT safely
If you and Dr. Ugwu decide HRT is right for you, here’s how to make it as safe and effective as possible:
- Get regular lab work to track hormone levels and adjust dosage
- Start low and go slow with doses
- Stick to follow-up appointments to track side effects
- Combine with healthy lifestyle habits
Dr. Ugwu may also recommend combining HRT with other therapies, like peptide therapy, thyroid support, or functional medicine practices.
Ultimately, HRT can be a safe and transformative treatment, especially when it’s personalized and closely monitored. The latest research supports its use in healthy individuals seeking to enhance their quality of life, manage hormone-related symptoms, and regain vitality.
If that’s you and you’re ready to learn more, call 830-455-3058 or use our online booking tool to schedule your appointment today!
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